For a sustainable and resource-efficient economy, residual and waste materials are recycled and fossil raw materials are replaced by renewable and secondary resources – the core of the circular bioeconomy. Waste, wastewater, and emissions are mainly generated in urban environments, with responsibility lying at the municipal or regional level. Fraunhofer IGB supports cities and regions in this transformation: Using the “urban BioEconomyLab” methodology, the institute analyzes the potential for creating value from previously unused residual materials and closing material cycles, as well as for designing regional and resilient supply chains in order to achieve a resource-efficient and sustainable economy based on biomass and the circular economy.