Three-Dimensional (3D) Animal Skin Models

We develop reconstituted skin models based on primary immortalized or primary skin cells of animal origin as in-vitro test systems. These 3D skin models are suitable for evaluating the efficacy and possible toxic side effects of therapeutic and skin care products on animal skin – completely without animal testing.

Reconstituted canine skin models 

are reconstituted dermis, epidermis and full-thickness skin models constructed from immortalized primary or primary canine skin cells.

Reconstituted equine skin models

are reconstituted dermis, epidermis and full-thickness skin models constructed from immortalized primary or primary equine skin cells.

Challenge: lack of in-vitro tissue models for testing veterinary products

A large number of different in-vitro tissue models are available for risk and efficacy studies in the preclinical development of human pharmaceuticals, but also for product development of cosmetics and chemical substances. The aim of these models is to reduce animal testing and to be able to make specific statements on the risk and efficacy of substances and products for humans. In contrast, animal experiments or ex-vivo tissue from living animals are still used for risk and efficacy studies in the veterinary field and for the development of care products for animals due to a lack of suitable in-vitro tissue models.

Similar to our human reconstituted dermis, epidermis and full-thickness skin models, we have also established corresponding in-vitro models for animals, for example for dogs, from immortalized primary or primary cells. 

Our development

With our decades of experience in the development of human cell lines, the establishment of human reconstituted 3D skin models and working to the highest quality standards, we establish animal reconstituted dermis, epidermis and full-thickness skin models.

Advantage: physiological 3D skin model

Our animal 3D skin models are based on specifically immortalized primary or primary skin cells of animal origin, which have been isolated from biopsies of medically indicated resections of healthy skin. By using immortalized primary cells, our skin models are donor-independent, reproducible and available at any time. Our reconstituted canine epidermis and full-thickness skin models have a horny layer and correspond to the in-vivo skin of the dog.