Fraunhofer Institute for Interfacial Engineering and Biotechnology IGBCell-based test systems realistically simulate the in-vivo situation and enable direct analysis of a cell reaction. We use vital mammalian cells as a diagnostic tool for our test systems. They are suitable for a wide range of test procedures in pharmaceutical research and in the development of new drugs, for example to investigate cell proliferation, toxicity, motility, and morphology. They thus enable targeted screening for new drugs and save time and money.
In addition to their use in drug screening, we have developed cell-based assay systems for the detection of pyrogens, e.g., bacterial residues that cause feverish reactions and even shock in humans. These are suitable for testing medical engineering devices and pharmaceutical formulations for pyrogenicity and can supplement or replace existing tests.
Cell-based test systems for determining biological parameters
Our non-clinical cell-based assays can be used to investigate various biological parameters of samples or substances.
Exemplary applications:
- Testing of bioactivity, cytotoxicity, and immunogenicity of compounds using immune receptor-based assays
- Screening of TLR agonists/antagonists
- Testing of antimicrobial properties of substances or surfaces
- Detection of pyrogens and microbial residues (pathogen-associated microbial patterns, PAMPs)
- Detection of viruses
