In-vitro diagnostics

The development and application of innovative methods concerning next-generation sequencing, as well as synthetic biology, are the main focus of the Functional Genomics research group headed by Dr. Kai Sohn. These methods provide the basis for the identification of biomarkers for personalized diagnostics of various clinical indications and the molecular analysis of infection processes, but also for the characterization of microorganisms in industrial biotechnology. Furthermore, methods for the qualitative and quantitative characterization of complex microbial metagenomes and metatranscriptomes are developed and applied to diagnostics and environmental biotechnology.

To this end, a complete workflow was established in our group to provide an 'all-in-one' solution from sample preparation to bioinformatics. Our automated sample preparation, next generation sequencing and high performance computing workflows are available for cooperation and joint research projects, as well as research projects of industrial clients.

Fields of activity and technologies

  • NGS-based diagnostics
  • Precision diagnostics and biomarkers
  • Microbiomics
  • Environmental genomics
  • Bioinformatics
 

From wet lab to dry lab: Functional genomics via next-generation sequencing

We perform next-generation sequencing (NGS) on behalf of our customers for de-novo sequencing of bacterial and fungal genomes, for transcriptional profile analyses, the identification of relevant genes and screening for diagnostic biomarkers.

 

Next-generation diagnostics

Despite good medical standards, there are still inadequate diagnostic procedures for many diseases to this day. We use next-generation sequencing technology to identify new biomarkers for improved diagnosis of, for example, prostate cancer, COPD or infectious diseases.

 

Genomics for white and environmental biotechnology

We also use NGS genome analyses to characterize microorganisms for industrial biotechnology. In addition, we develop methods for the qualitative and quantitative detection of complex microbial metagenomes and transcriptomes for environmental biotechnology.

Next Generation Sequencing Services

The Functional Genomics group has established a three-step process to handle inquiries for high throughput sequencing. This process, consisting of sample preparation, next generation sequencing and bioinformatics, is highly adaptive due to various established preprocessing and sample preparation protocols, as well as fast and flexible bioinformatics.

These characteristics enable a variety of applications, like de-novo genome and transcriptome sequencing of biotechnological production strains or human pathogens or meta-genomics and meta-transcriptomics, as well as facilitating early diagnosis of infectious and cancerous diseases.

Equipment

QIAcube (Qiagen)

  • automated sample preparation using Qiagen kits
  • up to 12 samples

 

Axio Observer.Z1 microscope (Zeiss)

  • ApoTome
  • fluorescence microscopy

 

BioAnalyzer 2100 (Agilent)

  • quality control, RNA and DNA quantification

 

Biomek Fx (Beckman Coulter)

  • automated sample preparation
  • individually programmable protocols

 

GS Junior (Roche)

  • pyrosequencing with long read length of up to 700 bp

 

HiSeq2500 (Illumina)

  • high throughput sequencing 
  • various kits for sample preparation to address different scientific problems

 

HPC

  • high-performance computing cluster with four computing units (100 CPUs, 770GB RAM)
  • backup via on-site tape library

Sample preparations

 

  • NA/RNA extraction established for various materials
    • Fungi and bacteria from pure cultures or directly from their biocenosis
    • Animal and plant tissues (incl. FFPE)
    • Blood, stool and environmental samples

 

  • Comprehensive repertoire of specific protocols available
    • DNA-Seq: whole genome shotgun (WGS),165 amplicons, enrichments
    • RNA-Seq: polyA+, small RNA, ncRNA, strand specificity, rRNA- and/or globin-depletions
    • Automation on Biomek FXP

 

Established NGS-technologies 

Sequencing with lllumina NextSeq 2000 Read length Reads/
Flowcell
Capacity/
Flowcell
Advantages
High output run mode 2 x 150 bases 1,1 bn 330 gb Universally applicable, high throughput
Rapid run mode 2 x 150 bases  400 Mio 120 gb Rapid data delivery time 

 

Information materials

 

Brochure “Next-Generation Sequencing”

Scientific publications

Jahr
Year
Titel/Autor:in
Title/Author
Publikationstyp
Publication Type
2023 Identification of two early blood biomarkers ACHE and CLEC12A for improved risk stratification of critically ill COVID-19 patients
Kattner, Simone; Müller, Jan; Glanz, Karolina; Manoochehri, Mehdi; Sylvester, Caroline Hannelore; Vainshtein, Yevhen; Berger, Marc Moritz; Brenner, Thorsten; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2023 IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils
Bénard, Alan; Mittelstädt, Anke; Klösch, Bettina; Glanz, Karolina; Müller, Jan; Schoen, Janina; Nüse, Björn; Brunner, Maximilian; Naschberger, Elisabeth; Stürzl, Michael; Mattner, Jochen; Muñoz, L. E.; Sohn, Kai; Grützmann, Robert; Weber, Georg Ferdinand
Zeitschriftenaufsatz
Journal Article
2023 Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease - from Early Cancer Detection to Individualized Cancer Treatment
David, Paul; Mittelstädt, Anke; Kouhestani, Dina; Anthuber, Anna; Kahlert, Christoph; Sohn, Kai; Weber, Georg Ferdinand
Review
2023 The 2‐methylpropene degradation pathway in Mycobacteriaceae family strains
Helbich, Steffen; Barrantes, Israel; Anjos Borges, Luiz Gustavo dos; Pieper, Dietmar H.; Vainshtein, Yevhen; Sohn, Kai; Engesser, Karl‐Heinrich
Zeitschriftenaufsatz
Journal Article
2023 From Gut to Blood: Spatial and Temporal Pathobiome Dynamics during Acute Abdominal Murine Sepsis
Hartwig, Christina; Drechsler, Susanne; Vainshtein, Yevhen; Maneth, Madeline; Schmitt, Theresa; Ehling-Schulz, Monika; Osuchowski, Marcin Filip; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2022 Transcriptome-proteome compendium of the Antarctic krill (Euphausia superba)
Möller, L.; Vainstein, Yevhen; Wöhlbrand, L.; Dörries, M.; Meyer, B.; Sohn, Kai; Rabus, R.
Zeitschriftenaufsatz
Journal Article
2021 Next-generation sequencing diagnostics of bacteremia in pediatric sepsis
Schmoch, T.; Westhoff, J.H.; Decker, S.O.; Skarabis, A.; Hoffmann, G.F.; Dohna-Schwake, C.; Felderhoff-Müser, U.; Skolik, C.; Feisst, M.; Klose, C.; Bruckner, T.; Luntz, S.; Weigand, M.A.; Sohn, K.; Brenner, T.
Zeitschriftenaufsatz
Journal Article
2021 Presence of viremia during febrile neutropenic episodes in patients undergoing chemotherapy for malignant neoplasms
Obrová, K.; Grumaz, Silke; Remely, M.; Czurda, S.; Krickl, I.; Herndlhofer, S.; Gleixner, K.V.; Sperr, W.R.; Größlinger, L.; Frank, T.; Andrade, N.; Egger-Matiqi, T.; Peters, C.; Engstler, G.; Dworzak, M.; Attarbaschi, A.; Grotel, M. van; Heuvel-Eibrink, M.M. van den; Moiseev, I.S.; Rogacheva, Y.; Zubarovskaya, L.; Zubarovskaya, N.; Pichler, H.; Lawitschka, A.; Koller, E.; Keil, F.; Valent, P.; Sohn, K.; Lion, T.
Zeitschriftenaufsatz
Journal Article
2020 Draft Genome Sequence of Andreprevotia sp. Strain IGB-42, a Chitinolytic Bacterium Isolated from a Soil Sample of an Anthill in Stuttgart, Germany
Vainshtein, Y.; Werner, Nicole; Kirstahler, Philipp; Glanz, K.; Grumaz, Christian; Hahn, T.; Zibek, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2020 Rapid Next-Generation Sequencing - Based Diagnostics of Bacteremia in Septic Patients
Grumaz, Christian; Hoffmann, A.; Vainshtein, Y.; Kopp, M.; Grumaz, Silke; Stevens, Philip; Decker, S.O.; Weigand, M.A.; Hofer, S.; Brenner, T.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2019 New approaches for the detection of invasive fungal diseases in patients following liver transplantation - results of an observational clinical pilot study
Decker, Sebastian O.; Krüger, Albert; Wilk, Henryk; Grumaz, Silke; Vainshtein, Yevhen; Schmitt, Felix C.F.; Uhle, Florian; Bruckner, Thomas; Zimmermann, Stefan; Mehrabi, Arianeb; Mieth, Markus; Weiss, Karl Heinz; Weigand, Markus A.; Hofer, Stefan; Sohn, Kai; Brenner, Thorsten
Zeitschriftenaufsatz
Journal Article
2019 Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties
Hosseinzadeh, A.; Stylianou, M.; Lopes, J.P.; Müller, D.C.; Häggman, A.; Holmberg, S.; Grumaz, Christian; Johansson, A.; Sohn, K.; Dieterich, C.; Urban, C.F.
Zeitschriftenaufsatz
Journal Article
2019 Obstructed defecation - an enteric neuropathy? An exploratory study of patient samples
Kim, M.; Rosenbaum, C.; Schlegel, N.; Grumaz, Christian; Sohn, K.; Isbert, C.; Walles, Heike; Metzger, M.
Zeitschriftenaufsatz
Journal Article
2019 Enhanced performance of next-generation sequencing diagnostics compared with standard of care microbiological diagnostics in patients suffering from septic shock
Grumaz, Silke; Grumaz, Christian; Vainshtein, Yevhen; Stevens, Philip; Glanz, Karolina; Decker, Sebastian O.; Hofer, Stefan; Weigand, Markus A.; Brenner, Thorsten; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2018 Localization and functional characterization of the pathogenesis-related proteins Rbe1p and Rbt4p in Candida albicans
Bantel, Y.; Darwiche, Rabih; Rupp, Steffen; Schneiter, Roger; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2018 Microbiome dynamics and adaptation of expression signatures during methane production failure and process recovery
Grohmann, Anja; Fehrmann, S.; Vainshtein, Y.; Haag, N.L.; Wiese, F.; Stevens, Philip; Naegele, H.-J.; Oechsner, H.; Hartsch, T.; Sohn, K.; Grumaz, Christian
Zeitschriftenaufsatz
Journal Article
2018 Genetic repertoires of anaerobic microbiomes driving generation of biogas
Grohmann, Anja; Vainshtein, Yevhen; Euchner, Ellen; Grumaz, Christian; Bryniok, Dieter; Rabus, Ralf; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2018 A novel cytochrome P450 mono‐oxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s
Worsch, Anne; Eggimann, Fabian K.; Girhard, Marco; Bühler, Clemens J. von; Tieves, Florian; Czaja, Rico; Vogel, Andreas; Grumaz, Christian; Sohn, Kai; Lütz, Stephan; Kittelmann, Matthas; Urlacher, Vlada B.
Zeitschriftenaufsatz
Journal Article
2018 Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial
Brenner, Thorsten; Decker, Sebastian O.; Grumaz, Silke; Stevens, Philip; Bruckner, Thomas; Schmoch, Thomas; Pletz, Mathias W.; Bracht, Hendrik; Hofer, Stefan; Marx, Gernot; Weigand, Markus A.; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2017 Immune cell-supplemented human skin model for studying fungal infections
Kühbacher, Andreas; Sohn, Kai; Burger-Kentischer, Anke; Rupp, Steffen
Aufsatz in Buch
Book Article
2017 Dual transcriptome of the immediate neutrophil and Candida albicans interplay
Niemiec, M.J.; Grumaz, Christian; Ermert, D.; Desel, C.; Shankar, M.; Lopes, J.P.; Mills, I.G.; Stevens, Philip; Sohn, K.; Urban, C.F.
Zeitschriftenaufsatz
Journal Article
2017 Draft genome sequences of three Actinobacteria strains presenting new candidate organisms with high potentials for specific P450 cytochromes
Grumaz, Christian; Vainshtein, Y.; Kirstahler, Philipp; Luetz, S.; Kittelmann, M.; Schroer, K.; Eggimann, F.K.; Czaja, R.; Vogel, A.; Hilberath, T.; Worsch, A.; Girhard, M.; Urlacher, V.B.; Sandberg, M.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2017 Immune-response patterns and next generation sequencing diagnostics for the detection of mycoses in patients with septic shock - results of a combined clinical and experimental investigation
Decker, S.O.; Sigl, A.; Grumaz, Christian; Stevens, Philip; Vainshtein, Y.; Zimmermann, S.; Weigand, M.A.; Hofer, S.; Sohn, K.; Brenner, T.
Zeitschriftenaufsatz
Journal Article
2017 Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay
Niemiec, M.J.; Grumaz, Christian; Ermert, D.; Desel, C.; Shankar, M.; Lopes, J.P.; Mills, I.G.; Stevens, Philip; Sohn, K.; Urban, C.F.
Zeitschriftenaufsatz
Journal Article
2017 Draft genome sequence of Pseudonocardia autotrophica strain DSM 43083, an efficient producer of peroxidases for lignin modification
Grumaz, Christian; Rais, Dominik; Kirstahler, Philipp; Vainshtein, Yevhen; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2017 The molecular blueprint of a fungus by next-generation sequencing (NGS)
Grumaz, Christian; Kirstahler, Philipp; Sohn, Kai
Aufsatz in Buch
Book Article
2017 Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion
Mailänder-Sánchez, D.; Braunsdorf, C.; Grumaz, Christian; Müller, C.; Lorenz, Stefan; Stevens, Philip; Wagener, J.; Hebecker, B.; Hube, B.; Bracher, F.; Sohn, K.; Schaller, M.
Zeitschriftenaufsatz
Journal Article
2017 Central role for dermal fibroblasts in skin model protection against Candida albicans
Kühbacher, Andreas; Henkel, H.; Stevens, Philip; Grumaz, Christian; Finkelmeier, D.; Burger-Kentischer, A.; Sohn, K.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2017 Method and device for nucleic acid based diagnostic approaches including the determination of a deviant condition, especially a health condition and/or pathogenic condition of a sample
Stevens, Philip; Sohn, Kai; Grumaz, Silke; Haeseler, Arndt von
Patent
2016 Transcriptomics and physiological analyses reveal co-ordinated alteration of metabolic pathways in Jatropha curcas drought tolerance
Sapeta, Helena; Lourenco, Tiago; Lorenz, Stefan; Grumaz, Christian; Kirstahler, Philipp; Barros, Pedro M.; Costa, Joaquim Miguel; Sohn, Kai; Oliveira, M. Margarida
Zeitschriftenaufsatz
Journal Article
2016 A method to identify protein antigens of Dermanyssus gallinae for the protection of birds from poultry mites
Makert, Gustavo R.; Vorbrüggen, Susanne; Krautwald-Junghanns, Maria-Elisabeth; Voss, Matthias; Sohn, Kai; Buschmann, Tilo; Ulbert, Sebastian
Zeitschriftenaufsatz
Journal Article
2016 Next-generation sequencing diagnostics of bacteremia in septic patients
Grumaz, Silke; Stevens, Philip; Grumaz, Christian; Decker, Sebastian O.; Weigand, Markus A.; Hofer, Stefan; Brenner, Thorsten; Haeseler, Arndt von; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2016 Advanced green biorefining: Effects of ensiling treatments on lactic acid production, microbial activity and supplementary methane formation of grass and rye
Haag, Nicola Leonard; Grumaz, Christian; Wiese, Franziska; Kirstahler, Philipp; Merkle, Wolfgang; Nägele, Hans-Joachim; Sohn, Kai; Jungbluth, Thomas; Oechsner, Hans
Zeitschriftenaufsatz
Journal Article
2015 Transcriptomic profiling of Pseudozyma aphidis during mannosylerythritol lipid synthesis
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, Kai; Zibek, Susanne; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2015 Stoffwechselanalysen in komplexen mikrobiellen Biozönosen
Stevens, Philip; Grumaz, Christian; Wiese, F.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2015 Anaerobe Batch-Fermentation mit Mais- und Amaranthsilagen: Biogasproduktion und molekulare Charakterisierung mikrobieller Gemeinschaften
Kempter-Regel, Brigitte; Grumaz, Christian; Wiese, Franziska; Scherge, Katharina; Birk, Carolin; Schließmann, Ursula; Stevens, Philip; Sohn, Kai; Bryniok, Dieter
Konferenzbeitrag
Conference Paper
2015 The transcriptomic profile of Pseudozyma aphidis during production of mannosylerythritol lipids
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, K.; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2015 Draft genome sequence of Amantichitinum ursilacus IGB-41, a new chitin-degrading bacterium
Kirstahler, Philipp; Günther, Michael; Grumaz, Christian; Lindemann, Elena; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2014 An in vivo photo-cross-linking approach reveals a homodimerization domain of Aha1 in S. cerevisiae
Berg, M.; Michalowski, A.; Palzer, Silke; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2014 Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids
Lorenz, Stefan; Günther, Michael; Grumaz, Christian; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2013 A family of secreted pathogenesis-related proteins in Candida albicans
Röhm, M.; Lindemann, Elena; Hiller, Ekkehard; Ermert, D.; Lemuth, Karin; Trkulja, D.; Sogukpinar, O.; Brunner, H.; Rupp, S.; Urban, C.F.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2013 Characterization of the protective and immunregulatory activity of probiotic lactobacilli in mucosal Candidiasis
Mailander-Sanchez, D.; Wagener, J.; Braunsdorf, C.; Grumaz, Christian; Lorenz, S.; Sohn, K.; Wehkamp, J.; Schaller, M.
Konferenzbeitrag
Conference Paper
2013 Metatranscriptome analysis reveals new insights in probiotic/host/Candida interaction in oral Candidiasis
Mailander-Sanchez, D.; Wagener, J.; Braunsdorf, C.; Grumaz, Christian; Lorenz, S.; Sohn, K.; Schaller, M.
Konferenzbeitrag
Conference Paper
2013 An expanded genetic code in Candida albicans to study protein-protein interactions in vivo
Palzer, Silke; Bantel, Y.; Kazenwadel, F.; Berg, M.; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2013 Species and condition specific adaptation of the transcriptional landscapes in Candida albicans and Candida dubliniensis
Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Schock, U.; Retey, J.; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2012 Differential metatranscriptomic profiling during Candida infections
Grumaz, Christian; Hoffmann, H.; Lorenz, Stefan; Lindemann, Elena; Stevens, Philip; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2012 Highly-integrated lab-on-chip system for point-of-care multiparameter analysis
Schumacher, Soeren; Nestler, Jörg; Otto, Thomas; Wegener, Michael; Ehrentreich-Förster, Eva; Michel, Dirk; Wunderlich, Kai; Palzer, Silke; Sohn, Kai; Weber, Achim; Burgard, Matthias; Grzesiak, Andrzej; Teichert, Andreas; Brandenburg, Albrecht; Koger, Birgit; Albers, Jörg; Nebling, Eric; Bier, Frank F.
Zeitschriftenaufsatz
Journal Article
2012 An expanded genetic code in Candida albicans to study molecular interactions in vivo
Palzer, Silke; Bantel, Y.; Kazenwadel, F.; Berg, M.; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2011 Adaptation, adhesion and invasion during interaction of Candida albicans with the host. Focus on the function of cell wall proteins
Hiller, Ekkehard; Zavrel, M.; Hauser, N.C.; Sohn, K.; Burger-Kentischer, A.; Lemuth, Karin; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2010 A multidimensional electrophoretic system of separation for the analysis of gene expression (MESSAGE)
Lindemann, Elena; Rohde, B.; Rupp, S.; Regenbogen, J.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2009 Characterization of genes encoding for cell surface proteins induced during hostpathogen interaction
Zavrel, M.; Hernandez, R.; Sohn, K.; Hauser, N.; Rupp, S.
Konferenzbeitrag
Conference Paper
2009 Host-pathogen interactions
Sammelband
Anthology
2009 Human epithelial model systems for the study of Candida infections in vitro. Pt.I: Adhesion to epithelial models
Sohn, K.; Rupp, S.
Aufsatz in Buch
Book Article
2008 Organotypical tissue cultures from adult murine colon as an in vitro model of intestinal mucosa
Bareiss, P.M.; Metzger, M.; Sohn, K.; Rupp, S.; Frick, J.S.; Autenrieth, I.B.; Lang, F.; Schwarz, H.; Skutella, T.; Just, L.
Zeitschriftenaufsatz
Journal Article
2007 A novel conserved nuclear localization signal is recognized by a group of yeast importins
Fries, T.; Betz, C.; Sohn, K.; Caesar, S.; Schlenstedt, G.; Bailer, S.
Zeitschriftenaufsatz
Journal Article
2006 An in vitro assay to study the transcriptional response during adherence of Candida albicans to different human epithelia
Sohn, K.; Senyürek, I.; Fertey, J.; Königsdorfer, A.; Joffroy, C.; Hauser, N.C.; Zelt, G.; Brunner, H.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2006 Getting in touch with Candida albicans: The cell wall of a fungal pathogen
Sohn, K.; Schwenk, J.; Urban, C.F.; Lechner, J.; Schweikert, M.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2006 Verbessertes elektrophoretisches Trennverfahren fuer die Analyse der Genexpression
Sohn, Kai; Rupp, S.
Patent
2006 Universelles Verfahren für die Genexpressionsanalyse
Lindemann, Elena; Rupp, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2006 Controlled cell attachment, using plasma deposited polymer microstructures: A novel study of cells-substrate interactions
Sciarratta, V.; Sohn, K.; Burger-Kentischer, A.; Brunner, H.; Oehr, Christian
Aufsatz in Buch
Book Article
2005 The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans
Urban, C.F.; Sohn, K.; Schröppel, K.; Brunner, H.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2005 Identification and Characterization of Cor33p, a novel protein implicated in tolerance towards oxidative stress in Candida albicans
Sohn, K.; Röhm, M.; Urban, C.F.; Saunders, N.; Rothenstein, D.; Lottspeich, F.; Schröppel, K.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2005 Thioredoxin-Peroxidase von C. albicans als virulenzspezifischer Marker
Urban, C.; Sohn, Kai; Brunner, H.; Rupp, S.
Patent
2005 Identification of covalently-linked proteins in the cell wall of C. albicans
Hiller, E.; Sohn, K.; Urban, Constantin; Gnau, V.; Nordheim, A.; Brunner, H.; Rupp, S.
Konferenzbeitrag
Conference Paper
2005 The transcriptional response in C. albicans during adhesion to mammalian epithelia
Sohn, K.; Senyürek, I.; Hauser, N.; Zelt, G.; Brunner, H.; Rupp, S.
Konferenzbeitrag
Conference Paper
2004 RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1
Lotz, H.; Sohn, K.; Brunner, H.; Mühlschlegel, F.A.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2003 Biochips mit Dimorphismus-spezifischen Faktoren aus Candida albicans
Sohn, Kai; Rupp, S.; Brunner, H.
Patent
2003 EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays
Sohn, K.; Urban, C.F.; Brunner, H.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2003 Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell
Urban, C.F.; Sohn, K.; Lottspeich, F.; Brunner, H.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2003 Identification of cell surface determinants in Candida albicans
Urban, C.F.; Sohn, K.; Lottspeich, F.; Schweikert, M.; Brunner, H.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2001 Regulation of cell wall dynamics in Candida albicans by CPH1 and EFG1, two transcription factors essential for virulence
Sohn, Kai; Urban, Constantin; Brunner, Herwig; Rupp, Steffen
Konferenzbeitrag
Conference Paper
2001 Hyphenspezifische Faktoren aus Candida albicans
Rupp, S.; Johannes, F.; Sohn, Kai
Patent
2000 A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics
Joos, T.O.; Schrenk, M.; Hopfl, P.; Kroger, K.; Chowdhury, U.; Stoll, D.; Schnorer, D.; Durr, M.; Herick, K.; Rupp, S.; Sohn, K.; Hammerle, H.
Zeitschriftenaufsatz
Journal Article
2000 Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins
Nölte, I.; Jeckel, D.; Wieland, F.T.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica

This list has been generated from the publication platform Fraunhofer-Publica