Bioprinting – R&D offer at a glance

Printing devices

• Jet-printer (Nanoplotter, GeSiM mbH, D; DMP 3000, Fujifilm, USA)
• Pneumatic or extrusion based dispenser (Prototype, Unitechnologies, CH; System 30, Hyrel3D, USA)

 

Biomaterials with adjustable properties

• Gelatin
• Collagen
• Hyaluronic acid
• Chondroitin sulfate
• Heparin    

 

Chemical modifications

For crosslinking

• methacrylic functions
• thio functions
• benzophenone

For reducing intermolecular interactions (masking)

• e.g. acetyl groups (DE 10 2012 219 691 B4 2015)    

 

Features and applications

• Control of viscosity
• Control of gelling behavior
• Crosslinked hydrogels with adjusted stiffness, swelling
• API storage with controlled release
• Biobased fluids with adjusted flow characteristics
• Cytocompatible or tissue-specific 3D matrices

 

Analysis

• NMR
• Rheology
• Compression testing at physiological conditions
• Cytocompatibility (according to DIN ISO)
• Pyrogen detection assay (cell-based)

 

Cells and tissues

• Primary cells isolated from human or mammalian biopsies, e.g. mesenchymal stem cells / chondrocytes, endothelial cells, mature adipocytes, skin cells  
• 2D and 3D culture
• Standard (immune)histological techniques and cell culture assays
• Flow cytometry for characterization of cells and cytokines